Mixed-mode C18 reversed-phase packing

C18 combined with cation/anion and normal-phase mixed-mode separation mechanism (120 Å, 10 μm, 20–30 μm) C18/cation-anion mixed-mode media: In addition to hydrophobic C18 functionality, cation and anion exchange groups are bonded onto the silica surface, enabling separation of ionic samples by adjusting mobile phase ionic strength and pH during reversed-phase separations. C18/normal-phase mixed-mode media: The silica surface is not fully end-capped, leaving a proportion of silanol groups to provide some separation capability for polar components. Purification method development is relatively challenging High mechanical strength for easy packing Stable performance with minimal batch-to-batch variability Manufactured in GMP-compliant facilities abroad