Construction of a Monoclonal Antibody Purification Platform Using Tosoh Resins

A robust and cost-effective antibody purification platform based on Tosoh resins

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2024.10_Chinaseminar_mAbplatformTOSOH_rev.0.pptx

This presentation describes how Tosoh resins can be used to build a robust and cost-effective purification platform for monoclonal antibodies. It begins with biopharmaceutical market trends and emphasizes that monoclonal antibodies remain the leading modality in both market size and pipeline. It then reviews the general three-step antibody purification workflow, in which Protein A capture is followed by intermediate and polishing steps to remove host cell proteins, DNA, aggregates, and other impurities. The presentation focuses on the process value of TOYOPEARL Super A, NH2-750F, and Phenyl FT-750F. Super A is presented as a high-performance Protein A resin with strong binding capacity, alkaline stability, mild elution behavior, and good flow properties, while NH2-750F and Phenyl FT-750F are positioned as efficient flow-through polishing tools that can reduce process complexity and potentially eliminate buffer exchange steps. Overall, the proposed Tosoh mAb platform is designed to improve robustness, maintain high product quality, and reduce downstream processing cost.